Effects of Lipid Lowering Therapy Optimization by PCSK9 Inhibitors on Circulating CD34+ Cells and Pulse Wave Velocity in Familial Hypercholesterolemia Subjects without Atherosclerotic Cardiovascular Disease: Real-World Data from Two Lipid Units.
Francesco PurrelloGiuseppe MandraffinoMichele ScuruchiAlberto Lo GulloAntonino Di PinoViviana FerraraCarmela MoraceCaterina Oriana AragonaGiovanni SquadritoFrancesco PurrelloSalvatore PiroPublished in: Biomedicines (2022)
PCSK9-i exhibited favorable effects on CD34 + CPCs as was on PWV values in a cohort of FH subjects. Our preliminary findings suggest a possible positive role of this novel lipid-lowering strategy on vascular homeostasis.