Neutrophilic asthma features increased airway classical monocytes.
Natalie M NiessenKatherine J BainesJodie Louise SimpsonHayley A ScottLing QinPeter G GibsonMichael FrickerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Flow cytometry allowed distinction of sputum macrophages, monocytes and subsets, revealing compartment-specific dysregulation of monocytes in asthma. We observed an increase in classical and CD206- monocytes in sputum in neutrophilic asthma, suggesting co-recruitment of monocytes and neutrophils to the airways in asthma. Our data suggest further investigation of how airway monocyte dysregulation impacts on asthma-related disease activity is merited.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- peripheral blood
- dendritic cells
- cystic fibrosis
- disease activity
- allergic rhinitis
- flow cytometry
- rheumatoid arthritis
- systemic lupus erythematosus
- mycobacterium tuberculosis
- pulmonary tuberculosis
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- machine learning
- electronic health record
- big data
- artificial intelligence
- drug induced