Fecal SN-38 Content as a Surrogate Predictor of Intestinal SN-38 Exposure and Associated Irinotecan-induced Severe Delayed-Onset Diarrhea by a Novel Use of the Spectrofluorimetric Method.

Zicong ZhengVesna Tumbas ŠaponjacRashim SinghJie ChenSongpol SrinualTaijun YinRongjin SunMing Hu

Published in: Pharmaceutical research (2024)

Fecal SN-38 content proves to be representative of intestinal exposure to SN-38, indicative of intestinal injury, and predictive of SDOD incidence in rats, while the spectrofluorimetric method demonstrates the translational potential.

Keyphrases

drug induced
risk factors
early onset
cross sectional
risk assessment
climate change
human health
irritable bowel syndrome
endothelial cells