Overexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15.

Ishita ChatterjeeYongguo ZhangJilei ZhangRong LuYinglin XiaJun Sun

Published in: Journal of Crohn's & colitis (2022)

We demonstrated the mechanism of VDR upregulation of Claudin-15 to protect against colitis. This might enlighten the mechanism of barrier dysfunction in IBD and potential therapeutic strategies to inhibit inflammation.

Keyphrases

oxidative stress
ulcerative colitis
cell proliferation
blood brain barrier
poor prognosis
signaling pathway
transcription factor
amino acid
human health
small molecule
climate change