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CRISPR technologies for precise epigenome editing.

Muneaki NakamuraYuchen GaoAntonia A DominguezLei S Qi
Published in: Nature cell biology (2021)
The epigenome involves a complex set of cellular processes governing genomic activity. Dissecting this complexity necessitates the development of tools capable of specifically manipulating these processes. The repurposing of prokaryotic CRISPR systems has allowed for the development of diverse technologies for epigenome engineering. Here, we review the state of currently achievable epigenetic manipulations along with corresponding applications. With future optimization, CRISPR-based epigenomic editing stands as a set of powerful tools for understanding and controlling biological function.
Keyphrases
  • crispr cas
  • genome editing
  • dna methylation
  • genome wide
  • copy number
  • gene expression
  • current status