Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT).
Malia S Q MurphyKatherine A MuldoonHauna SheyholislamiNathalie BehanYvonne LamersNatalie RybakRuth Rennicks WhiteAlysha L J HarveyLaura M GaudetGraeme N SmithMark C WalkerShi Wu WenAmanda J MacFarlanePublished in: The American journal of clinical nutrition (2021)
High-dose FA supplementation in early pregnancy increases maternal serum folate but not RBC folate concentrations, suggesting tissue saturation. Higher UMFA concentrations in women receiving high-dose FA supplements suggest that these doses are supraphysiologic but with no evidence of altered 1-carbon metabolism.