DNA methylation suppresses chitin degradation and promotes the wing development by inhibiting Bmara-mediated chitinase expression in the silkworm, Bombyx mori.

Guanfeng XuYangqin YiHao LyuChengcheng GongQili FengQisheng SongXuezhen PengLin LiuSi-Chun Zheng

Published in: Epigenetics & chromatin (2020)

This study reveals that DNA methylation plays an important role in the wing development of B. mori. Our results support that the indirect transcriptional repression of a chitin degradation-related gene BmCHT10 by DNA methylation is necessary to keep the proper wing development in B. mori.

Keyphrases

dna methylation
genome wide
gene expression
copy number
signaling pathway
poor prognosis
transcription factor
oxidative stress
long non coding rna
heat shock protein