PPARs and Angiogenesis-Implications in Pathology.
Nicole WagnerKay-Dietrich WagnerPublished in: International journal of molecular sciences (2020)
Peroxisome proliferator-activated receptors (PPARs) belong to the family of ligand-activated nuclear receptors. The PPAR family consists of three subtypes encoded by three separate genes: PPARα (NR1C1), PPARβ/δ (NR1C2), and PPARγ (NR1C3). PPARs are critical regulators of metabolism and exhibit tissue and cell type-specific expression patterns and functions. Specific PPAR ligands have been proposed as potential therapies for a variety of diseases such as metabolic syndrome, cancer, neurogenerative disorders, diabetes, cardiovascular diseases, endometriosis, and retinopathies. In this review, we focus on the knowledge of PPAR function in angiogenesis, a complex process that plays important roles in numerous pathological conditions for which therapeutic use of PPAR modulation has been suggested.
Keyphrases
- insulin resistance
- metabolic syndrome
- cardiovascular disease
- fatty acid
- type diabetes
- endothelial cells
- healthcare
- adipose tissue
- vascular endothelial growth factor
- dna methylation
- squamous cell carcinoma
- climate change
- genome wide
- papillary thyroid
- weight loss
- uric acid
- squamous cell
- wound healing
- glycemic control
- bioinformatics analysis