Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension.
A Dushani C U RanasingheMaggie HolohanKalyn M BorgerDeborah L DonahueRafael D KucMartin GerigAndrew KimVictoria A PloplisFrancis J CastellinoMargaret A SchwarzPublished in: Circulation research (2023)
SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.