Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations.
Alexander PopDina Halegoua-DeMarzioHuiman BarnhartDavid KleinerMark AviganJiezhun GuNaga ChalasaniJawad AhmadRobert J FontanaWilliam LeeA Sidney BarrittFrancisco DurazoPaul H HayashiVictor J NavarroPublished in: Digestive diseases and sciences (2024)
Amiodarone hepatotoxicity resembles that seen in alcohol related liver injury, with fatty infiltration and inflammation. Dronedarone is less predictable, typically without fat and with a shorter latency of use before presentation. These differences may be explained, in part, by the differing pharmacokinetics of the two drugs leading to different mechanisms of hepatotoxicity.