L-type voltage-gated calcium channels in stem cells and tissue engineering.
Yi-Zhou TanDong-Dong FeiXiao-Ning HeJi-Min DaiRong-Chen XuXin-Yue XuJun-Jie WuBei LiPublished in: Cell proliferation (2019)
L-type voltage-gated calcium ion channels (L-VGCCs) have been demonstrated to be the mediator of several significant intracellular activities in excitable cells, such as neurons, chromaffin cells and myocytes. Recently, an increasing number of studies have investigated the function of L-VGCCs in non-excitable cells, particularly stem cells. However, there appear to be no systematic reviews of the relationship between L-VGCCs and stem cells, and filling this gap is prescient considering the contribution of L-VGCCs to the proliferation and differentiation of several types of stem cells. This review will discuss the possible involvement of L-VGCCs in stem cells, mainly focusing on osteogenesis mediated by mesenchymal stem cells (MSCs) from different tissues and neurogenesis mediated by neural stem/progenitor cells (NSCs). Additionally, advanced applications that use these channels as the target for tissue engineering, which may offer the hope of tissue regeneration in the future, will also be explored.
Keyphrases
- stem cells
- tissue engineering
- induced apoptosis
- mesenchymal stem cells
- cell cycle arrest
- cell therapy
- systematic review
- signaling pathway
- gene expression
- endoplasmic reticulum stress
- oxidative stress
- spinal cord
- randomized controlled trial
- spinal cord injury
- subarachnoid hemorrhage
- atomic force microscopy
- case control