Meta-Analysis of IBD Gut Samples Gene Expression Identifies Specific Markers of Ileal and Colonic Diseases.

Kevin PerezMarjolaine NgolloKeren RabinowitzNassim HammoudiPhilippe SeksikRamnik J XavierMark J DalyIris DotanLionel Le BourhisMatthieu Allez

Published in: Inflammatory bowel diseases (2022)

We demonstrated that ileal and colonic diseases exhibit specific signatures, independent of their initial clinical classification. This supports molecular, rather than clinical, disease stratification, and may be used to design drugs specifically targeting ileal or colonic diseases.

Keyphrases

gene expression
ulcerative colitis
systematic review
genome wide
dna methylation
machine learning
randomized controlled trial
drug delivery
case control