Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities.

Jairo RamosChangwon YooQuentin FeltyZhenghua GongJuan P LiuzziRobert PoppitiIndu Shekhar ThakurRuchika GoelAshok Kumar VaidRicardo Jorge KomotarNasreen Z EhteshamSeyed E HasnainDeodutta Roy

Published in: Journal of cancer research and clinical oncology (2020)

Our findings showed how sensitivity to high NRF1 transcriptional activity coupled with its target gene signatures contribute to racial differences in luminal A and TN breast cancer subtypes. This knowledge may be useful in personalized intervention to prevent and treat this clinically challenging problem.

Keyphrases

genome wide
oxidative stress
copy number
randomized controlled trial
healthcare
genome wide identification
dna methylation
transcription factor
heat shock
young adults
health insurance
childhood cancer