Interrogation of TERT promoter hotspot mutations in ameloblastoma and ameloblastic carcinoma.
Maria Carolina Silva Versieux MagalhãesFernanda Aragão FélixLetícia Martins GuimarãesJean Nunes Dos SantosLuiz Armando de MarcoHélder Antônio Rebelo PontesCarolina Cavaliéri GomesSílvia Ferreira de SousaPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
The absence of TERT promoter mutation in the samples indicates that this molecular event is not relevant to the tumors' pathogenesis. Further studies are necessary to explore undefined genetic or epigenetic mechanisms related to TERT-upregulation in ameloblastoma, and the telomerase activity in ameloblastic carcinoma.