Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca2+ -activated K+ channel (BKCa ) upregulation.
Xiaoxue ShenLing ZhangLing JiangWenjie XiongYurong TangLin LinTing YuPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
In conclusion, S1P and S1PR2 participate in age-associated contractile dysfunction via BKCa upregulation through PKCζ , JNK, and NF-κB pathways.