Altered Expression of RB and pRB in Tissue Arrays of Primary Breast Cancers and Matched Axillary Lymph Node Metastases.
Carmen LeserAngelika ReinerGeorg DorffnerMarie-Theres KastnerMartin IgazChristian SingerDeirdre Maria König-CastilloChristine DeutschmannDaniel KönigIris HolzerDaphne Gschwantler-KaulichPublished in: The breast journal (2022)
Expression of pRB and E2F1 was significantly higher in LM than in primary BC. A majority of cancers with LM showed altered RB or pRB expression, suggesting that proteins downstream in the RB pathway play a critical role in metastatic BC and disease progression. So looking at the RB pathway could be an option for chemotherapy decisions in patients with only few LM.