Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress.
Yaodong HeWei WangPingping JiangLin YangQi GuoJunwei XiangYuling GaoYuanyin WangRan ChenPublished in: Journal of inflammation research (2021)
Many studies have shown that most genomes are transcribed into non-coding RNAs (ncRNAs), including microRNAs (miRs) and long non-coding RNAs (lncRNAs), which can affect different cell characteristics. LncRNAs are long heterologous RNAs that regulate gene expression and various signaling pathways during homeostasis and development. Studies have shown that a lncRNA is an important regulatory molecule that can be targeted to change the physiology and function of cells. Expression or dysfunction of lncRNAs is closely related to various genetic, autoimmune, and metabolic diseases. The importance of ncRNAs in oral submucosal fibrosis (OSF) has garnered much attention in recent years. However, most research has focused on miRs. The role of these molecules in OSF is incompletely understood. This review focuses on the emerging role and function of lncRNAs in OSF as novel regulators. Finally, the potential functional role of lncRNAs as biomarkers for OSF diagnosis is also described. LncRNAs are expected to become a new therapeutic target, but more research is needed to understand their biological functions more deeply.
Keyphrases
- long non coding rna
- poor prognosis
- network analysis
- gene expression
- genome wide analysis
- genome wide identification
- transcription factor
- signaling pathway
- induced apoptosis
- single cell
- oxidative stress
- multiple sclerosis
- working memory
- stem cells
- cell proliferation
- genome wide
- pi k akt
- epithelial mesenchymal transition
- liver fibrosis