Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective.
Raffaele RaimondiPiero ZolletFrancesco Paolo De RosaPanagiotis A TsoutsanisMatteo StravalaciMarianna PaulisAntonio InforzatoMario R RomanoPublished in: International journal of molecular sciences (2022)
The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.
Keyphrases
- replacement therapy
- optical coherence tomography
- diabetic retinopathy
- smoking cessation
- age related macular degeneration
- embryonic stem cells
- induced pluripotent stem cells
- healthcare
- optic nerve
- induced apoptosis
- palliative care
- cell cycle arrest
- drinking water
- oxidative stress
- randomized controlled trial
- systematic review
- cell death
- endoplasmic reticulum stress
- cell proliferation