Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.

Sean A HardyNishani S MabotuwanaLucy A MurthaBrianna CoulterSonia Sanchez-BezanillaMohammed S Al-OmaryTharindu SenanayakeSvenja LoeringMalcolm StarkeyRandall J LeePeter P RainerPhilip M HansbroAndrew J Boyle

Published in: PloS one (2019)

ECM1 expression is increased in ageing and infarcted hearts but is not expressed by resident cardiac cells. Instead it is expressed by bone marrow-derived granulocytes. ECM1 is sufficient to induce cardiac fibroblast stimulation in vitro. Our findings suggest ECM1 is released from infiltrating inflammatory cells, which leads to cardiac fibroblast stimulation and fibrosis in aging and MI. ECM1 may be a novel intermediary between inflammation and fibrosis.

Keyphrases

extracellular matrix
left ventricular
induced apoptosis
oxidative stress
cell cycle arrest
heart failure
poor prognosis
endoplasmic reticulum stress
signaling pathway
cell proliferation
cell death
liver fibrosis
quality improvement
atrial fibrillation