Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.
Michael O HarhayJonathan Dale CaseyMarina ClementSean P CollinsÉtienne GayatMichelle Ng GongSamir JaberPierre-François LaterreJohn C MarshallMichael A MatthayRhonda E MonroeTodd W RiceEileen RubinWesley H SelfAlexandre MebazaaPublished in: Intensive care medicine (2020)
The 3CT Workshop participants identified opportunities to improve critical care trials using strategies to optimize sample size calculations, account for patient and disease heterogeneity, increase the efficiency of trial conduct, maximize the use of trial data, and to refine and standardize the collection of patient-centered and patient-informed outcome measures beyond mortality.
Keyphrases
- clinical trial
- phase ii
- phase iii
- study protocol
- case report
- open label
- computed tomography
- randomized controlled trial
- molecular dynamics
- cardiovascular events
- density functional theory
- single cell
- coronary artery disease
- cardiovascular disease
- magnetic resonance imaging
- dual energy
- contrast enhanced
- machine learning
- deep learning
- double blind