Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells.
Ki-Wook KimSeung-Hoon YangJong-Bae KimPublished in: Evidence-based complementary and alternative medicine : eCAM (2014)
Mistletoe (Viscum Album coloratum) has been known as a medicinal plant in European and Asian countries. Recent data show that biological activity of mistletoe alleviates hypertension, heart disease, renal failure, and cancer development. In this study, we report the antidiabetic effect of Korean mistletoe extract (KME). KME treatments enhanced the insulin secretion from the pancreatic β -cell without any effects of cytotoxicity. PDX-1 and beta2/neuroD known as transcription factors that regulate the expression of insulin gene were upregulated by treatment of the KME protein fractions isolated by ion-exchange chromatography after ammonium sulfate precipitation. Furthermore, these KME protein fractions significantly lowered the blood glucose level and the volume of drinking water in alloxan induced hyperglycemic mice. Taken together with the findings, it provides new insight that KME might be served as a useful source for the development of medicinal reagent to reduce blood glucose level of type I diabetic patients.
Keyphrases
- blood glucose
- drinking water
- glycemic control
- blood pressure
- type diabetes
- binding protein
- protein protein
- transcription factor
- oxidative stress
- induced apoptosis
- poor prognosis
- mass spectrometry
- amino acid
- health risk assessment
- health risk
- stem cells
- cell therapy
- electronic health record
- single cell
- gene expression
- pulmonary hypertension
- risk assessment
- mouse model
- high glucose
- deep learning
- combination therapy
- young adults
- copy number
- adipose tissue
- bone marrow
- weight loss
- long non coding rna
- machine learning
- arterial hypertension
- stress induced
- squamous cell
- endothelial cells