Implications of two-component systems EnvZ/OmpR and BaeS/BaeR in in vitro temocillin resistance in Escherichia coli.

Patricia Pérez-Palacios José Luis Rodríguez-OchoaAna Velázquez-EscuderoJesús Rodríguez-Baño José Manuel Rodríguez-Martínez Alvaro Pascual Fernando Docobo-Pérez

Published in: The Journal of antimicrobial chemotherapy (2024)

Mutations in the sensor histidine kinase, baeS, may be involved in temocillin resistance through the expression of the efflux pumps mdtABC and acrD. In addition, the low mutation rate may be a good predictor of temocillin activity.

Keyphrases

escherichia coli
poor prognosis
tyrosine kinase
binding protein
cystic fibrosis