Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin.

Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly( N -vinylcaprolactam- co -hyaluronic acid) (p(VCL- co -HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.