A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection.
Gregory Thomas KennedyDavid E HoltFeredun S AzariElizabeth BernsteinBilal NadeemAshley E ChangNeil T SullivanAlix SegilCharuhas DesphandeEric BensenJohn T SantiniJohn C KucharczukEdward J DelikatnyMatthew BogyoA J Matthew EganCharles W BradleyEvgeniy B EruslanovJason D LickliterGavin WrightSunil SinghalPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
This first-in-human study demonstrates the safety and feasibility of VGT-309 to label human pulmonary tumors during resection. These results may be generalizable to other cancers due to cathepsin overexpression in many solid tumors.