Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial.
Nattaphol UransilpPannawat ChaiyawatthanananthnSombat MuengtaweepongsaPublished in: Neurology research international (2018)
High-dose simvastatin might be helpful to reduce serum sLOX-1. But no difference in clinical outcomes was found between high- and low-dose simvastatin. Further more intensive clinical trial is needed to confirm the appropriate dosage of simvastatin in patients with acute ischemic stroke. This trial is registered with ClinicalTrials.gov ID: NCT03402204.
Keyphrases
- acute ischemic stroke
- high dose
- low dose
- clinical trial
- double blind
- study protocol
- stem cell transplantation
- phase iii
- oxidative stress
- phase ii
- open label
- placebo controlled
- randomized controlled trial
- dna damage
- type diabetes
- metabolic syndrome
- diabetic rats
- adipose tissue
- insulin resistance
- signaling pathway
- skeletal muscle
- heat shock protein