Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.

Min Jung ParkJun-Woo AhnKi Hyung KimJunghee BangSeung Chul KimJae Yi JeongYe Eun ChoiChang-Woon KimBo Sun Joo

Published in: Experimental biology and medicine (Maywood, N.J.) (2020)

Ovarian aging is becoming a more important issue in terms of fertility preservation and infertility treatment. Serum anti-Mullerian hormone (AMH) level and antral follicle count (AFC) are being practically used as markers of ovarian aging as well as ovarian reserve in human. However, these factors have some drawbacks in assessing ovarian aging and reserve. Therefore, the identification of ovarian expressions of BMP15, GDF9, and C-KIT according to female could be applied as a potent predictor of ovarian aging. This work provides new information on the development of diagnosis and treatment strategy of age-related fertility decline and premature ovarian insufficiency.

Keyphrases

endothelial cells
mesenchymal stem cells
healthcare
type diabetes
poor prognosis
skeletal muscle
long non coding rna
metabolic syndrome
social media
replacement therapy