Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice.
Hu ChenYunlong LuRui XiongCarlo I RosalesCassandre ColesKana HamadaNuria AsadGregory R J ThatcherAmy W LasekPublished in: Alcoholism, clinical and experimental research (2022)
These results indicate that SERD treatment can decrease binge-like ethanol drinking in female mice. Thus, it could be a novel strategy to reduce binge drinking in women, with the caveat that effectiveness may depend on menstrual cycle phase. In addition, Esr1 transcript is increased by binge ethanol exposure in both sexes but in a brain region-specific manner.