Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice.

Hu ChenYunlong LuRui XiongCarlo I RosalesCassandre ColesKana HamadaNuria AsadGregory R J ThatcherAmy W Lasek

Published in: Alcoholism, clinical and experimental research (2022)

These results indicate that SERD treatment can decrease binge-like ethanol drinking in female mice. Thus, it could be a novel strategy to reduce binge drinking in women, with the caveat that effectiveness may depend on menstrual cycle phase. In addition, Esr1 transcript is increased by binge ethanol exposure in both sexes but in a brain region-specific manner.

Keyphrases

estrogen receptor
alcohol consumption
high fat diet induced
resting state
white matter
randomized controlled trial
systematic review
functional connectivity
type diabetes
cerebral ischemia
adipose tissue
insulin resistance
metabolic syndrome
single cell