Inositol-Requiring Enzyme 1α-Mediated Synthesis of Monounsaturated Fatty Acids as a Driver of B Cell Differentiation and Lupus-like Autoimmune Disease.
Yana ZhangMing GuiYajun WangNikita ManiShuvam ChaudhuriBeixue GaoHuabin LiYashpal S KanwarSarah A LewisSabrina N DumasJames M NtambiKezhong ZhangDeyu FangPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
The results of this study reveal a molecular link in the dysregulation of lipid metabolism in the pathogenesis of lupus, demonstrating that the IRE-1α/XBP-1 pathway controls plasma cell differentiation through SCD-1/SCD-2-mediated monounsaturated fatty acid synthesis. These findings provide a rationale for targeting IRE-1α and monounsaturated fatty acid synthesis in the treatment of patients with SLE.