Exploration of the Shared Gene Signatures and Molecular Mechanisms Between Ischemic Stroke and Atherosclerosis.
Ru BanChengju HuoJingru WangGuifeng ZhangXin ZhaoPublished in: International journal of general medicine (2024)
We integrated ischemic stroke and carotid atherosclerosis public database data and found that ATF3, CCL3, CCL4, JUNB, KRAS, and ZC3H12A may affect both, making them novel biomarkers or therapeutic target genes. Clinical samples and expression trends supported our analyses of pivotal genes.
Keyphrases
- genome wide
- genome wide identification
- cardiovascular disease
- transcription factor
- atrial fibrillation
- dna methylation
- liver fibrosis
- liver injury
- poor prognosis
- genome wide analysis
- copy number
- healthcare
- bioinformatics analysis
- mental health
- electronic health record
- adverse drug
- big data
- drug induced
- gene expression
- binding protein
- endoplasmic reticulum stress
- type diabetes
- deep learning