Understanding the link between obesity and severe COVID-19 outcomes: Causal mediation by systemic inflammatory response.
Andrea S FoulkesCaitlin SelvaggiDaniel ShinnickHeidi LumishEunyoung KimTingyi CaoTanayott ThaweethaiJing QianFrances LuJoyce YanDavid ChengWei HeKevin J ClerkinMahesh V MadhavanJames B MeigsVirginia A TriantSteven A LubitzAakriti GuptaIngrid V BassettMuredach P ReillyPublished in: The Journal of clinical endocrinology and metabolism (2021)
Findings support systemic inflammatory pathways in obesity-associated severe COVID-19 disease, particularly in patients <65 years, captured by CRP and ESR. Contextualized in clinical trials findings, these results reveal therapeutic opportunity to target systemic inflammatory pathways and monitor interventions in high-risk subgroups and particularly obese patients.
Keyphrases
- obese patients
- coronavirus disease
- inflammatory response
- sars cov
- weight loss
- bariatric surgery
- clinical trial
- insulin resistance
- metabolic syndrome
- end stage renal disease
- type diabetes
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early onset
- roux en y gastric bypass
- high fat diet induced
- drug induced
- gastric bypass
- prognostic factors
- genome wide
- adipose tissue
- randomized controlled trial
- respiratory syndrome coronavirus
- gene expression
- dna methylation
- depressive symptoms
- lps induced
- skeletal muscle
- body mass index