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The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).

Aowen ZhuangFelicia Y T YapDanielle J BorgDomenica McCarthyAmelia FotheringhamSherman LeungSally A PenfoldKarly C SourrisMelinda T CoughlanBenjamin L SchulzJosephine M Forbes
Published in: Endocrinology, diabetes & metabolism (2021)
These studies indicate that increased podocyte expression of oligosaccharyltransferase-48 kDa subunit results in glomerular endoplasmic reticulum stress and a decline in kidney function.
Keyphrases
  • endoplasmic reticulum stress
  • diabetic nephropathy
  • high glucose
  • induced apoptosis
  • poor prognosis
  • endothelial cells
  • binding protein
  • heat shock protein
  • case control
  • protein kinase
  • signaling pathway