The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).
Aowen ZhuangFelicia Y T YapDanielle J BorgDomenica McCarthyAmelia FotheringhamSherman LeungSally A PenfoldKarly C SourrisMelinda T CoughlanBenjamin L SchulzJosephine M ForbesPublished in: Endocrinology, diabetes & metabolism (2021)
These studies indicate that increased podocyte expression of oligosaccharyltransferase-48 kDa subunit results in glomerular endoplasmic reticulum stress and a decline in kidney function.