Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer.

Hey Min Lee Ajay Kumar Saw Van Karlyle Morris Stefania Napolitano Christopher A Bristow Sanjana Srinivasan Michael D Peoples Alexey V Sorokin Preeti Kanikarla Jonathan Schulz Anand Kamal Singh Christopher J Terranova Oluwadara Coker Abhinav K Jain Edmund S Kopetz Kunal Rai

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

In conclusion, DNA hypomethylation by 5-azacitidine exhibits a close association with H3K27me3 and PRC activity in BRAFV600E CRC, and simultaneous blockade of DNMT and EZH2 holds promise as a potential therapeutic strategy for patients with BRAFV600E-mutated CRC.

Keyphrases

dna methylation
genome wide
gene expression
acute myeloid leukemia
circulating tumor
single molecule
copy number
long non coding rna
long noncoding rna
machine learning
nucleic acid
artificial intelligence