A manual propofol infusion regimen for neonates and infants.

James Denzil Morse Jacqueline A Hannam Luis Ignacio Cortinez Karel Allegaert Brian Joseph Anderson

Published in: Paediatric anaesthesia (2019)

Propofol clearance increases throughout infancy to reach 92% that reported in adults (1.93 L.min.70 kg-1 ) by 6 months postnatal age and infusion regimens should reflect clearance maturation and be cognizant of adverse effects from concentrations greater than the target plasma concentration. Predicted concentrations using a published general purpose pharmacokinetic propofol model were similar to those determined using a new parameter set using richer neonatal and infant data.

Keyphrases

low dose
preterm infants
electronic health record
low birth weight
big data
randomized controlled trial
weight gain
body mass index
machine learning
deep learning