Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute Brucellosis.

Guang XuPeng ZhangRongjing DangYanfang Jiang Feng WangBin WangMingyuan Yang

Published in: Mediators of inflammation (2019)

The IFN-γ levels secreted by Th1 cells remain significantly higher than those of healthy subjects more than 12 months after treatment with antibiotics. This finding is different from similar studies. The IFN-γ/TNF-α ratio may be a feasible parameter for assessing clinical severity, yet further longitudinal studies of the immunization and inflammatory reaction of brucellosis are needed in larger patient populations.

Keyphrases

dendritic cells
immune response
rheumatoid arthritis
induced apoptosis
case control
liver failure
cell cycle arrest
oxidative stress
case report
drug induced
cross sectional
aortic dissection
intensive care unit
hepatitis b virus
cell proliferation
pi k akt