Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to human.

Published in: Evolution, medicine, and public health (2020)

This study analyses whole-genome and spike sequences of coronavirus from NCBI using phylogenetic and conservation analyses to reconstruct the evolutionary history of severe acute respiratory syndrome (SARS)-CoV-2 and proposes an evolutionary history of spike in the progenitors of SARS-CoV-2 from bat to human through mammal hosts before they recombine into the current form.

Keyphrases

sars cov
respiratory syndrome coronavirus
endothelial cells
induced pluripotent stem cells
pluripotent stem cells
genome wide
case report
gene expression
coronavirus disease
respiratory tract