BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression.
Yanjie HuangFangfang DaiLiping ChenZhidian LiHua LiuYan-Xiang ChengPublished in: Endocrinology (2024)
Our findings highlighted the downregulation of BMP4 in both RSA patients and mice. BMP4 in human endometrial stromal cells was shown to modulate decidualization by regulating FOXO1 expression. Loss of BMP4 may contribute to the pathogenesis of RSA, suggesting potential avenues for abortion prevention strategies.
Keyphrases
- mesenchymal stem cells
- endothelial cells
- poor prognosis
- bone regeneration
- end stage renal disease
- signaling pathway
- transcription factor
- induced pluripotent stem cells
- newly diagnosed
- chronic kidney disease
- ejection fraction
- pi k akt
- cell proliferation
- endometrial cancer
- peritoneal dialysis
- type diabetes
- metabolic syndrome
- bone marrow
- risk assessment
- patient reported outcomes
- patient reported
- climate change
- skeletal muscle