Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.
Mev Dominguez-ValentinJulian R SampsonToni T SeppäläSanne W Ten BroekeJohn-Paul PlazzerSigve NakkenChristoph EngelStefan AretzMark A JenkinsLone SundeInge BernsteinGabriel CapellaFrancesc BalaguerHuw ThomasD Gareth EvansJohn BurnMarc GreenblattEivind HovigWouter H de Vos Tot Nederveen CappelRolf H SijmonsLucio BertarioMaria Grazia TibilettiGiulia Martina CavestroAnnika LindblomAdriana Della ValleFrancisco Lopez-KöstnerNathan GluckLior H KatzKarl HeinimannCarlos A VaccaroReinhard BüttnerHeike GörgensElke Holinski-FederMonika MorakStefanie HolzapfelRobert HüneburgMagnus von Knebel DoeberitzMarkus LoefflerNils RahnerHans K SchackertVerena Steinke-LangeWolff SchmiegelDeepak VangalaKirsi PylvänäinenLaura Renkonen-SinisaloJohn L HopperAung Ko WinRobert W HaileNoralane M LindorSteven GallingerLoïc Le MarchandPolly A NewcombJane C FigueiredoStephen N ThibodeauKarin WadtChristina TherkildsenHenrik OkkelsZohreh KetabiLeticia MoreiraAriadna SánchezMiquel Serra-BurrielMarta PinedaMatilde NavarroIgnacio BlancoKate GreenFiona LallooEmma J CrosbieJames HillOliver G DentonIan M FraylingEinar Andreas RødlandHans VasenMiriam MintsFlorencia NeffaPatricia EsperonKarin AlvarezRevital KarivGuy RosnerTamara Alejandra PineroMaría Laura GonzalezPablo KalfayanDouglas TjandraIngrid M WinshipFinlay MacraeGabriela MösleinJukka-Pekka MecklinMaartje NielsenPål MøllerPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.