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Toni T Seppälä (Toni Seppälä, T T Seppälä)

ResearcherID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2023
Publications (10 Years): 26

Top Venues

Cancers

Journal of clinical medicine

Nature communications

Cancer research communications

Johns Hopkins School of Medicine

University of Eastern Finland (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Johns Hopkins School of Medicine Aug 5o 2019

United States

Research Fellow :: Surgery

Education History

University of Eastern Finland

Finland

PHD :: School of Medicine

Publications

Minttu Kansikas, Laura Vähätalo, Jukka Kantelinen, Mariann Kasela, Jaana Putula, Anni Døhlen, Pauliina Paloviita, Emmi Kärkkäinen, Niklas Lahti, Philippe Arnez, Sami K Kilpinen, Beatriz Alcala-Repo, Kirsi Pylvänäinen, Minna Pöyhönen, Päivi Peltomäki, Heikki J Järvinen, Toni T Seppälä, Laura Renkonen-Sinisalo, Anna Lepistö, Jukka-Pekka Mecklin, Minna Nyström
Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity. Cancer research communications 3 (3) (2023)
Toni T Seppälä, Richard A Burkhart, Bryson W Katona
Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review. BJS open 7 (3) (2023)
Minttu Kansikas, Laura Vähätalo, Jukka Kantelinen, Mariann Kasela, Jaana Putula, Anni Døhlen, Pauliina Paloviita, Emmi Kärkkäinen, Niklas Lahti, Philippe Arnez, Sami K Kilpinen, Beatriz Alcala-Repo, Kirsi Pylvänäinen, Minna Pöyhönen, Päivi Peltomäki, Heikki J Järvinen, Toni T Seppälä, Laura Renkonen-Sinisalo, Anna Lepistö, Jukka-Pekka Mecklin, Minna Nyström
Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity. Cancer research communications 3 (3) (2023)
Toni T Seppälä, Richard A Burkhart, Bryson W Katona
Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review. BJS open 7 (3) (2023)
John Cummings Mathers, Faye Elliott, Finlay A Macrae, Jukka-Pekka Mecklin, Gabriela Moeslein, Fiona E McRonald, Lucio Bertario, Dafydd Gareth Evans, Anne-Marie Gerdes, Judy W C Ho, Annika Lindblom, Patrick John Morrison, Jem Rashbass, Rajkumar Ramesar, Toni T Seppälä, Huw J W Thomas, Harsh J Sheth, Kirsi Pylvänäinen, Lynn Reed, Gillian M Borthwick, D Timothy Bishop, John Burn, null null
Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up. Cancer prevention research (Philadelphia, Pa.) 15 (9) (2022)
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T Seppälä, Erkki-Ville Wirta, Eero Sihvo, Juha P Väyrynen, Fredrik Yannopoulos, Olli Helminen
CD3 + and CD8 + T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer. Cancers 15 (1) (2022)
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T Seppälä, Erkki-Ville Wirta, Eero Sihvo, Juha P Väyrynen, Fredrik Yannopoulos, Olli Helminen
CD3 + and CD8 + T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer. Cancers 15 (1) (2022)
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T Seppälä, Erkki-Ville Wirta, Eero Sihvo, Juha P Väyrynen, Fredrik Yannopoulos, Olli Helminen
CD3 + and CD8 + T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer. Cancers 15 (1) (2022)
Toni T Seppälä, Jacquelyn W Zimmerman, Reecha Suri, Haley Zlomke, Gabriel D Ivey, Annamaria Szabolcs, Christopher R Shubert, John L Cameron, William R Burns, Kelly J Lafaro, Jin He, Christopher L Wolfgang, Ying S Zou, Lei Zheng, David A Tuveson, James R Eshlemann, David P Ryan, Alec C Kimmelman, Theodore S Hong, David Tsai Ting, Elizabeth D Thompson, Richard Andrew Burkhart
Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (15) (2022)
Mev Dominguez-Valentin, John-Paul Plazzer, Julian R Sampson, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capellá Munar, Francesc Balaguer, Finlay Macrae, Ingrid M Winship, Huw Thomas, Dafydd Gareth Evans, John Burn, Marc Greenblatt, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, Maartje Nielsen, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Annika Lindblom, Adriana Della Valle, Francisco Lopez-Kostner, Karin Alvarez, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos Alberto Vaccaro, Sigve Nakken, Eivind Hovig, Kate Green, Fiona Lalloo, James Hill, Hans F A Vasen, Claudia Perne, Reinhard Büttner, Heike Görgens, Elke Holinski-Feder, Monika Morak, Stefanie Holzapfel, Robert Hueneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Jürgen Weitz, Verena Steinke-Lange, Wolff Schmiegel, Deepak Ben Vangala, Emma J Crosbie, Marta Pineda, Matilde Navarro, Joan Brunet, Leticia Moreira, Ariadna Sánchez, Miquel Serra-Burriel, Miriam Mints, Revital Kariv, Guy Rosner, Tamara Alejandra Piñero, Walter Hernán Pavicic, Pablo Kalfayan, Sanne W Ten Broeke, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Päivi Peltomäki, John L Hopper, Aung-Ko Win, Daniel D Buchanan, Noralane M Lindor, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, Jane C Figueiredo, Stephen N Thibodeau, Christina Therkildsen, Thomas V O Hansen, Lars Lindberg, Einar Andreas Rødland, Florencia Neffa, Patricia Esperón, Douglas Tjandra, Gabriela Möslein, Toni T Seppälä, Pål Møller
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study. Journal of clinical medicine 10 (13) (2021)
Ilmo Kellokumpu, Matti Kairaluoma, Jukka-Pekka Mecklin, Henrik Kellokumpu, Ville Väyrynen, Erkki-Ville Wirta, Eero Sihvo, Teijo Kuopio, Toni T Seppälä
Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study. Journal of clinical medicine 10 (8) (2021)
Toni T Seppälä, A Latchford, I Negoi, A Sampaio Soares, Rosa María Jiménez-Rodríguez, Luís Sánchez-Guillén, D G Evans, N Ryan, E J Crosbie, M Dominguez-Valentin, J Burn, M Kloor, M von Knebel Doeberitz, F J B van Duijnhoven, P Quirke, J R Sampson, P Møller, G Möslein, null null
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender. The British journal of surgery 108 (5) (2021)
Tero Sievänen, Timo Törmäkangas, Eija K Laakkonen, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Toni T Seppälä, Päivi Peltomäki, Sarianna Sipilä, Elina Sillanpää
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome. Cancers 13 (8) (2021)
Maarit Ahtiainen, Hanna Elomaa, Juha P Väyrynen, Erkki-Ville Wirta, Teijo Kuopio, Olli Helminen, Toni T Seppälä, Ilmo Kellokumpu, Jukka-Pekka Mecklin
Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases. Cancers 13 (7) (2021)
Satu Mäki-Nevala, Sanjeevi Ukwattage, Erkki-Ville Wirta, Maarit Ahtiainen, Ari Ristimäki, Toni T Seppälä, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki
Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis. Biomolecules 11 (10) (2021)
Aysel Ahadova, Pauline Luise Pfuderer, Maarit Ahtiainen, Alexej Ballhausen, Lena Bohaumilitzky, Svenja Kösegi, Nico Müller, Yee Lin Tang, Kosima Kosmalla, Johannes Witt, Volker Endris, Albrecht Stenzinger, Magnus von Knebel Doeberitz, Hendrik Bläker, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Toni T Seppälä, Matthias Kloor
Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance. Journal of clinical medicine 10 (11) (2021)
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni T Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel-Doeberitz, Matthias Kloor
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution. Nature communications 11 (1) (2020)
Mev Dominguez-Valentin, Toni T Seppälä, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capellá Munar, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos Alberto Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Ben Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan Brunet Vidal, Revital Kariv, Guy Rosner, Tamara Alejandra Piñero, María Laura Gonzalez, Pablo Kalfayan, Julian R Sampson, Neil A J Ryan, D Gareth Evans, Pål Møller, Emma J Crosbie
Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database. Journal of clinical medicine 9 (7) (2020)
Mev Dominguez-Valentin, Julian R Sampson, Pål Møller, Toni T Seppälä, null null
Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum. International journal of cancer 148 (2) (2020)
Toni T Seppälä, A Latchford, I Negoi, A Sampaio Soares, Rosa María Jiménez-Rodríguez, Luís Sánchez-Guillén, D G Evans, N Ryan, E J Crosbie, M Dominguez-Valentin, J Burn, M Kloor, M von Knebel Doeberitz, F J B van Duijnhoven, P Quirke, J R Sampson, P Møller, G Möslein, null null
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender. The British journal of surgery (2020)
Erkki-Ville Wirta, Säde Szeto, Ulrika Hänninen, Maarit Ahtiainen, Jan Böhm, Jukka-Pekka Mecklin, Lauri A Aaltonen, Toni T Seppälä
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions. Cancers 12 (8) (2020)
Toni T Seppälä, Aysel Ahadova, Mev Dominguez-Valentin, Finlay Macrae, D Gareth Evans, Christina Therkildsen, Julian Sampson, Rodney Scott, John Burn, Gabriela Möslein, Inge Bernstein, Elke Holinski-Feder, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Charlotte Kvist Lautrup, Annika Lindblom, John-Paul Plazzer, Ingrid Winship, Douglas Tjandra, Lior H Katz, Stefan Aretz, Robert Hüneburg, Stefanie Holzapfel, Karl Heinimann, Adriana Della Valle, Florencia Neffa, Nathan Gluck, Wouter H de Vos Tot Nederveen Cappel, Hans Vasen, Monika Morak, Verena Steinke-Lange, Christoph Engel, Nils Rahner, Wolff Schmiegel, Deepak Vangala, Huw Thomas, Kate Green, Fiona Lalloo, Emma J Crosbie, James Hill, Gabriel Capella, Marta Pineda, Matilde Navarro, Ignacio Blanco, Sanne Ten Broeke, Maartje Nielsen, Ken Ljungmann, Sigve Nakken, Noralane Lindor, Ian Frayling, Eivind Hovig, Lone Sunde, Matthias Kloor, Jukka-Pekka Mecklin, Mette Kalager, Pål Møller
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report. Hereditary cancer in clinical practice 17 (2019)
Maarit Ahtiainen, Erkki-Ville Wirta, Teijo Kuopio, Toni T Seppälä, Juha Rantala, Jukka-Pekka Mecklin, Jan Böhm
Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 32 (6) (2019)
Tatiana Cajuso, Päivi Sulo, Tomas Tanskanen, Riku Katainen, Aurora Taira, Ulrika A Hänninen, Johanna Kondelin, Linda Forsström, Niko Välimäki, Mervi Aavikko, Eevi Kaasinen, Ari Ristimäki, Selja Koskensalo, Anna Lepistö, Laura Renkonen-Sinisalo, Toni T Seppälä, Teijo Kuopio, Jan Böhm, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Kimmo Palin, Lauri A Aaltonen
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival. Nature communications 10 (1) (2019)
Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppälä, Sanne W Ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, Lucio Bertario, Maria Grazia Tibiletti, Giulia Martina Cavestro, Annika Lindblom, Adriana Della Valle, Francisco Lopez-Köstner, Nathan Gluck, Lior H Katz, Karl Heinimann, Carlos A Vaccaro, Reinhard Büttner, Heike Görgens, Elke Holinski-Feder, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Hans K Schackert, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, John L Hopper, Aung Ko Win, Robert W Haile, Noralane M Lindor, Steven Gallinger, Loïc Le Marchand, Polly A Newcomb, Jane C Figueiredo, Stephen N Thibodeau, Karin Wadt, Christina Therkildsen, Henrik Okkels, Zohreh Ketabi, Leticia Moreira, Ariadna Sánchez, Miquel Serra-Burriel, Marta Pineda, Matilde Navarro, Ignacio Blanco, Kate Green, Fiona Lalloo, Emma J Crosbie, James Hill, Oliver G Denton, Ian M Frayling, Einar Andreas Rødland, Hans Vasen, Miriam Mints, Florencia Neffa, Patricia Esperon, Karin Alvarez, Revital Kariv, Guy Rosner, Tamara Alejandra Pinero, María Laura Gonzalez, Pablo Kalfayan, Douglas Tjandra, Ingrid M Winship, Finlay Macrae, Gabriela Möslein, Jukka-Pekka Mecklin, Maartje Nielsen, Pål Møller
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genetics in medicine : official journal of the American College of Medical Genetics 22 (1) (2019)
Jutta Lappalainen, Darja Holmström, Anna Lepistö, Juha Saarnio, Jukka-Pekka Mecklin, Toni T Seppälä
Incident colorectal cancer in Lynch syndrome is usually not preceded by compromised quality of colonoscopy. Scandinavian journal of gastroenterology 54 (12) (2019)

Toni T Seppälä.css-eqlu8i{font-size:small;padding-left:4px;} (Toni Seppälä, T T Seppälä)

Publication Activity (10 Years)

Top Topics

Top Venues

Toni T Seppälä (Toni Seppälä, T T Seppälä)