Impact of immunohistochemical expression of kinesin family member 18A (Kif18A) and β-catenin in infiltrating breast carcinoma of no special type.

Aiat Shaban HemidaMohammed Ibrahim ShabaanMennatallah Ahmed TahaAsmaa Gaber Abdou

Published in: World journal of surgical oncology (2024)

KIF18A could be involved in breast carcinogenesis by activating β-catenin. Overexpression of KIF18A and aberrant expression of β-catenin are considered proto-oncogenes of breast cancer development. KIF18A and β-catenin could be poor prognostic markers and predictors of aggressive behavior of breast cancer.

Keyphrases

cell proliferation
epithelial mesenchymal transition
poor prognosis
signaling pathway
binding protein
transcription factor
young adults
breast cancer risk