Total-body imaging of mu-opioid receptors with [ 11 C]carfentanil in non-human primates.
Chia-Ju HsiehCatherine HouHsiaoju LeeCosette TomitaAlexander SchmitzKonstantinos PlakasJacob G DubroffRobert H MachPublished in: European journal of nuclear medicine and molecular imaging (2024)
C]CFN total-body PET scans could be a useful approach for studying mechanism of action of MOR drugs used in the treatment of acute and chronic opioid use disorder and their effect on the biodistribution of synthetic opioids such as CFN. GSK1521498 could be a potential naloxone alternative to reverse opioid overdose.
Keyphrases
- chronic pain
- pain management
- computed tomography
- endothelial cells
- drug induced
- liver failure
- pet imaging
- high resolution
- positron emission tomography
- signaling pathway
- respiratory failure
- induced pluripotent stem cells
- magnetic resonance
- intensive care unit
- pi k akt
- risk assessment
- combination therapy
- cell proliferation
- mass spectrometry
- hepatitis b virus
- human health
- aortic dissection
- fluorescence imaging