Robert H Mach

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 53

Top Topics

Oxidative Stress

Room Temperature

Top Venues

ACS chemical neuroscience

International journal of molecular sciences

Journal of medicinal chemistry

Pharmaceuticals (Basel, Switzerland)

This page only lists publications with an associated author ORCID identifier.

Publications

Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C Luk, Robert H Mach, Meagan J McManus
Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy. International journal of molecular sciences 25 (9) (2024)
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G Dubroff, Robert H Mach
Total-body imaging of mu-opioid receptors with [ 11 C]carfentanil in non-human primates. European journal of nuclear medicine and molecular imaging (2024)
Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C Luk, Robert H Mach, Meagan J McManus
Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy. International journal of molecular sciences 25 (9) (2024)
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G Dubroff, Robert H Mach
Total-body imaging of mu-opioid receptors with [ 11 C]carfentanil in non-human primates. European journal of nuclear medicine and molecular imaging (2024)
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G Dubroff, Robert H Mach
Total-body imaging of mu-opioid receptors with [ 11 C]carfentanil in non-human primates. European journal of nuclear medicine and molecular imaging 51 (11) (2024)
Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C Luk, Robert H Mach, Meagan J McManus
Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy. International journal of molecular sciences 25 (9) (2024)
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G Dubroff, Robert H Mach
Total-body imaging of mu-opioid receptors with [ 11 C]carfentanil in non-human primates. European journal of nuclear medicine and molecular imaging 51 (11) (2024)
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach
Correction: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI research 13 (1) (2023)
Ho Young Kim, Wai Kit Chia, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J A Graham, Zsofia Lengyel-Zhand, Mark Schneider, Cosette Tomita, Marshall G Lougee, Hee Jong Kim, Vinayak V Pagar, Hsiaoju Lee, Catherine Hou, Benjamin A Garcia, E James Petersson, Jennifer O'Shea, Paul T Kotzbauer, Chester A Mathis, Virginia M-Y Lee, Kelvin C Luk, Robert H Mach
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy. Journal of medicinal chemistry (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Chia-Ju Hsieh, Sam Giannakoulias, E James Petersson, Robert H Mach
Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development. Pharmaceuticals (Basel, Switzerland) 16 (2) (2023)
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Robert R Luedtke, Robert H Mach
Design and Synthesis of D 3 R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies. Molecules (Basel, Switzerland) 29 (1) (2023)
Thomas J A Graham, Anton Lindberg, Junchao Tong, Jeffrey S Stehouwer, Neil Vasdev, Robert H Mach, Chester A Mathis
In Silico Discovery and Subsequent Characterization of Potent 4R-Tauopathy Positron Emission Tomography Radiotracers. Journal of medicinal chemistry (2023)
Ana María Estrada-Sánchez, Claudia Rangel-Barajas, Andrew G Howe, Scott J Barton, Robert H Mach, Robert R Luedtke, George V Rebec
Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing. International journal of molecular sciences 24 (11) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience (2023)
Bashar M Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca Serena Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H Mach, Nunzio Denora, Byung-Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, Michael A Cahill
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97. International journal of molecular sciences 24 (7) (2023)
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Robert R Luedtke, Robert H Mach
Design and Synthesis of D 3 R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies. Molecules (Basel, Switzerland) 29 (1) (2023)
Bieneke Janssen, Guilong Tian, Zsofia Lengyel-Zhand, Chia-Ju Hsieh, Marshall G Lougee, Aladdin Riad, Kuiying Xu, Catherine Hou, Chi-Chang Weng, Brian J Lopresti, Hee Jong Kim, Vinayak V Pagar, John J Ferrie, Benjamin A Garcia, Chester A Mathis, Kelvin Luk, E James Petersson, Robert H Mach
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search. Molecular imaging and biology (2023)
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach
Correction: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI research 13 (1) (2023)
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Robert R Luedtke, Robert H Mach
Design and Synthesis of D 3 R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies. Molecules (Basel, Switzerland) 29 (1) (2023)
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach
Correction: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI research 13 (1) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience (2023)
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J Izzo, Susan M Catalano, Thomas J A Graham, Robert H Mach
Screening of σ 2 Receptor Ligands and In Vivo Evaluation of 11 C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ 2 Receptor Brain PET Tracer. Journal of medicinal chemistry 65 (8) (2022)
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Michelle Taylor, Robert R Luedtke, Robert H Mach
Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D 3 -Selective Antagonists. International journal of molecular sciences 24 (1) (2022)
Chi-Chang Weng, Aladdin Riad, Brian P Lieberman, Kuiying Xu, Xin Peng, John L Mikitsh, Robert H Mach
Characterization of Sigma-2 Receptor-Specific Binding Sites Using [ 3 H]DTG and [ 125 I]RHM-4. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
Austin Ryan Pantel, Sarah B Gitto, Mehran Makvandi, Hyoung Kim, Sergey Medvedv, Joanna K Weeks, Drew A Torigian, Chia-Ju Hsieh, Benjamin Ferman, Nawar A Latif, Janos L Tanyi, Lainie P Martin, Shannon M Lanzo, Fang Liu, Quy Cao, Gordon B Mills, Robert K Doot, David A Mankoff, Robert H Mach, Lilie L Lin, Fiona Simpkins
[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a pilot study. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
Robert K Doot, Anthony J Young, Ilya M Nasrallah, Reagan R Wetherill, Andrew Siderowf, Robert H Mach, Jacob G Dubroff
[ 18 F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease. Cells 11 (19) (2022)
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Michelle Taylor, Robert R Luedtke, Robert H Mach
Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D 3 -Selective Antagonists. International journal of molecular sciences 24 (1) (2022)
Chi-Chang Weng, Aladdin Riad, Brian P Lieberman, Kuiying Xu, Xin Peng, John L Mikitsh, Robert H Mach
Characterization of Sigma-2 Receptor-Specific Binding Sites Using [ 3 H]DTG and [ 125 I]RHM-4. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach
[ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI research 12 (1) (2022)
Hsiaoju S Lee, Sally W Schwarz, Erin K Schubert, Delphine L Chen, Robert K Doot, Mehran Makvandi, Lilie L Lin, Elizabeth S McDonald, David A Mankoff, Robert H Mach
The Development of 18 F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiology. Imaging cancer 4 (1) (2022)
Chi-Chang Weng, Aladdin Riad, Brian P Lieberman, Kuiying Xu, Xin Peng, John L Mikitsh, Robert H Mach
Characterization of Sigma-2 Receptor-Specific Binding Sites Using [ 3 H]DTG and [ 125 I]RHM-4. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Chi-Chang Weng, Aladdin Riad, Brian P Lieberman, Kuiying Xu, Xin Peng, John L Mikitsh, Robert H Mach
Characterization of Sigma-2 Receptor-Specific Binding Sites Using [ 3 H]DTG and [ 125 I]RHM-4. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Michelle Taylor, Robert R Luedtke, Robert H Mach
Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D 3 -Selective Antagonists. International journal of molecular sciences 24 (1) (2022)
Marshall G Lougee, Vinayak Vishnu Pagar, Hee Jong Kim, Samantha X Pancoe, W Kit Chia, Robert H Mach, Benjamin A Garcia, E James Petersson
Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods. Chemical communications (Cambridge, England) 58 (65) (2022)
Laura N Puentes, Zsofia Lengyel-Zhand, Sean W Reilly, Robert H Mach
Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease. Molecular neurobiology 58 (8) (2021)
Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M-Y Lee, John Q Trojanowski, Robert H Mach
The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Molecular neurobiology 57 (9) (2020)
Zsofia Lengyel-Zhand, John J Ferrie, Bieneke Janssen, Chia-Ju Hsieh, Thomas Graham, Kui-Ying Xu, Conor M Haney, Virginia M-Y Lee, John Q Trojanowski, E James Petersson, Robert H Mach
Synthesis and characterization of high affinity fluorogenic α-synuclein probes. Chemical communications (Cambridge, England) 56 (24) (2020)
Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R Benjamin Free, Sean W Reilly, Robert R Luedtke, Peter Århem, Francisco Ciruela, David R Sibley, Robert H Mach, Jana Selent, Johanna Nilsson, Kristoffer Sahlholm
Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism. ACS chemical neuroscience 11 (19) (2020)
Sean W Reilly, Aladdin A Riad, Chia-Ju Hsieh, Kristoffer Sahlholm, Daniel A Jacome, Suzy Griffin, Michelle Taylor, Chi-Chang Weng, Kuiying Xu, Nathan Kirschner, Robert R Luedtke, Christopher Parry, Shipra Malhotra, John Karanicolas, Robert H Mach
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs). Journal of medicinal chemistry 62 (10) (2019)
Heinz H Coenen, Antony D Gee, Michael Adam, Gunnar Antoni, Cathy S Cutler, Yasuhisa Fujibayashi, Jae Min Jeong, Robert H Mach, Thomas L Mindt, Victor W Pike, Albert D Windhorst
Open letter to journal editors on: International consensus radiochemistry nomenclature guidelines. Journal of labelled compounds & radiopharmaceuticals 61 (4) (2019)
Mehran Makvandi, Hwan Lee, Laura N Puentes, Sean W Reilly, Komal S Rathi, Chi-Chang Weng, Ho Sze Chan, Catherine Hou, Pichai Raman, Daniel Martinez, Kuiying Xu, Sean D Carlin, Roger A Greenberg, Bruce R Pawel, Robert H Mach, John M Maris, Daniel A Pryma
Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models. Molecular cancer therapeutics 18 (7) (2019)
Chia-Ju Hsieh, John J Ferrie, Kuiying Xu, Iljung Lee, Thomas J A Graham, Zhude Tu, Jennifer Yu, Dhruva Dhavale, Paul Kotzbauer, E James Petersson, Robert H Mach
Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules. ACS chemical neuroscience 9 (11) (2018)
Hoang D Lu, Leon Z Wang, Brian K Wilson, Simon A McManus, Jenny Jumai'an, Prashanth K Padakanti, Abass Alavi, Robert H Mach, Robert K Prud'homme
Copper Loading of Preformed Nanoparticles for PET-Imaging Applications. ACS applied materials & interfaces 10 (4) (2018)
Sean W Reilly, Laura N Puentes, Khadija Wilson, Chia-Ju Hsieh, Chi-Chang Weng, Mehran Makvandi, Robert H Mach
Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. Journal of medicinal chemistry 61 (12) (2018)
Sean W Reilly, Mehran Makvandi, Kuiying Xu, Robert H Mach
Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature. Organic letters 20 (7) (2018)
Catherine Hou, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Thomas J Graham, Kuiying Xu, Chi-Chang Weng, Robert K Doot, Wenhua Chu, Subhasish K Chakraborty, Laura L Dugan, Mark A Mintun, Robert H Mach
Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. ACS chemical neuroscience 9 (3) (2017)
Sean W Reilly, Suzy Griffin, Michelle Taylor, Kristoffer Sahlholm, Chi-Chang Weng, Kuiying Xu, Daniel A Jacome, Robert R Luedtke, Robert H Mach
Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. Journal of medicinal chemistry 60 (23) (2017)
Robert H Mach, Robert R Luedtke
Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies. Journal of labelled compounds & radiopharmaceuticals 61 (3) (2017)