Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.
Kyle D KlingbeilBlake R WildeDanielle S GrahamSerena LofftusTyler R McCawNedas MatulionisSarah M DryJoseph G CromptonFritz Christian EilberThomas Glen GraeberDavid B ShackelfordHeather R ChristofkBrian E KaderaPublished in: Cancers (2024)
Asn enrichment and mTORC1 upregulation are important factors contributing to WD/DD LPS tumor progression. Effective targeting strategies require limiting access to extracellular Asn and inhibition of de novo synthesis mechanisms. The combination of PEG-Asnase with ETC inhibition is an effective therapy to restrict tumor growth in WD/DD LPS.