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Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.

Kyle D KlingbeilBlake R WildeDanielle S GrahamSerena LofftusTyler R McCawNedas MatulionisSarah M DryJoseph G CromptonFritz Christian EilberThomas Glen GraeberDavid B ShackelfordHeather R ChristofkBrian E Kadera
Published in: Cancers (2024)
Asn enrichment and mTORC1 upregulation are important factors contributing to WD/DD LPS tumor progression. Effective targeting strategies require limiting access to extracellular Asn and inhibition of de novo synthesis mechanisms. The combination of PEG-Asnase with ETC inhibition is an effective therapy to restrict tumor growth in WD/DD LPS.
Keyphrases
  • poor prognosis
  • inflammatory response
  • cancer therapy
  • anti inflammatory
  • drug delivery
  • cell proliferation
  • signaling pathway
  • stem cells
  • long non coding rna