Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

Judith LechnerMei ChenRuth E HoggLevente TothGiuliana SilvestriUsha ChakravarthyHeping Xu

Published in: Journal of neuroinflammation (2017)

PBMCs, in particular monocytes, may contribute to CNV development in nAMD through secreting elevated levels of IL-8, CCL2 and VEGF after they are recruited to the macula. Apart from VEGF, IL-8 and CCL2 may be additional targets for nAMD management.

Keyphrases

age related macular degeneration
vascular endothelial growth factor
end stage renal disease
liver fibrosis
liver injury
endothelial cells
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
drug induced
patient reported outcomes
patient reported
peripheral blood