The Contribution of Subthalamic Nucleus Deep Brain Stimulation to the Improvement in Motor Functions and Quality of Life.
Inken TödtBassam Al-FatlyOliver GranertAndrea A KühnPaul KrackJoern RauLars TimmermannAlfons SchnitzlerSteffen PaschenAnn-Kristin HelmersAndreas HartmannEric BardinetMichael SchuepbachMichael T BarbeTill A DembekValérie FraixDorothee KüblerChristine Brefel-CourbonAlireza GharabaghiLars WojteckiMarcus O PinskerStephane ThoboisPhilippe DamierTatiana WitjasJean-Luc HouetoCarmen Schade-BrittingerMarie VidailhetAndreas HornGuenther DeuschlPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
The main influence of DBS on QoL is likely mediated through the sensory-motor basal ganglia loop. The PDQ sweet spot is located in a posteroventral spatial location in the STN territory. For aspects of QoL, however, there was also evidence of improvement through stimulation of the other STN subnuclei. More research is necessary to customize the DBS target to individual symptoms of each patient. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.