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Improved total synthesis of the antibiotic A54145B.

Hoi Yee ChowDelin ChenXuechen Li
Published in: Organic & biomolecular chemistry (2020)
A54145B is a calcium-dependent cyclic lipodepsipeptide antibiotic that is active against Gram-positive pathogens. Herein, we report an improved synthetic route toward A54145B in terms of the yield and time required. The key changes include using a pre-assembled minimalist tetradepsipeptide building block to solve the difficult on-resin esterification from our previous synthetic route, and a new macrocyclization site to avoid the peptide self-cleavage problem.
Keyphrases
  • gram negative
  • multidrug resistant
  • dna binding