Xuechen Li

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 69

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Chemical science

Organic letters

Harvard University (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Harvard University

United States

PHD :: Chemistry and Chemical Biology

Publications

Xing Guo, Yan Chu Cheung, Can Li, Han Liu, Pengfei Li, Sheng Chen, Xuechen Li
Investigation on the substrate specificity and N -substitution tolerance of PseF in catalytic transformation of pseudaminic acids to CMP-Pse derivatives. Chemical science 15 (16) (2024)
Yisa Xiao, Haiyan Zhou, Han Liu, Xuechen Li
Trifluoroacetic Acid Mediated Additive-Free Late-Stage Native Peptide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones. Organic letters 26 (30) (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society (2024)
Heng Liu, Hoi Yee Chow, Jiamei Liu, Pengfei Shi, Xuechen Li
Prior disulfide bond-mediated Ser/Thr ligation. Chemical science (2024)
Yisa Xiao, Haiyan Zhou, Pengfei Shi, Xueqian Zhao, Han Liu, Xuechen Li
Clickable tryptophan modification for late-stage diversification of native peptides. Science advances 10 (28) (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society 146 (10) (2024)
Yisa Xiao, Haiyan Zhou, Han Liu, Xuechen Li
Trifluoroacetic Acid Mediated Additive-Free Late-Stage Native Peptide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones. Organic letters (2024)
Heng Liu, Hoi Yee Chow, Jiamei Liu, Pengfei Shi, Xuechen Li
Prior disulfide bond-mediated Ser/Thr ligation. Chemical science (2024)
Peizhong Chen, Xiong Chen, Xiaolei Song, An He, Yong Zheng, Xuechen Li, Rui-Jun Tian
Dissecting phospho-motif-dependent Shc1 interactome using long synthetic protein fragments. Chemical science (2024)
Qiushi Chen, Zhiwu Tan, Yang Tang, Yi Man Eva Fung, Sheng Chen, Zhiwei Chen, Xuechen Li
Comprehensive Glycomic and Glycoproteomic Analyses of Human Programmed Cell Death Protein 1 Extracellular Domain. Journal of proteome research (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society 146 (10) (2024)
Xuemei Yang, Ruohan Wei, Han Liu, Tongyao Wei, Ping Zeng, Yan Chu Cheung, Heng Heng, Edward Waichi Chan, Xuechen Li, Sheng Chen
Discovery of a Monoclonal Antibody That Targets Cell-Surface Pseudaminic Acid of Acinetobacter baumannii with Direct Bactericidal Effect. ACS central science 10 (2) (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society 146 (10) (2024)
Xuemei Yang, Ruohan Wei, Han Liu, Tongyao Wei, Ping Zeng, Yan Chu Cheung, Heng Heng, Edward Waichi Chan, Xuechen Li, Sheng Chen
Discovery of a Monoclonal Antibody That Targets Cell-Surface Pseudaminic Acid of Acinetobacter baumannii with Direct Bactericidal Effect. ACS central science 10 (2) (2024)
Hongxiang Wu, Zhenquan Sun, Xuechen Li
Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S-Benzylidene Thioacetals. Angewandte Chemie (International ed. in English) (2024)
Hongxiang Wu, Zhenquan Sun, Xuechen Li
Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S-Benzylidene Thioacetals. Angewandte Chemie (International ed. in English) 63 (19) (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society 146 (10) (2024)
Yisa Xiao, Haiyan Zhou, Pengfei Shi, Xueqian Zhao, Han Liu, Xuechen Li
Clickable tryptophan modification for late-stage diversification of native peptides. Science advances 10 (28) (2024)
Abraham Olusegun Oluwole, Víctor M Hernández-Rocamora, Yihui Cao, Xuechen Li, Waldemar Vollmer, Carol V Robinson, Jani Reddy Bolla
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics. Journal of the American Chemical Society 146 (10) (2024)
Xing Guo, Yan Chu Cheung, Can Li, Han Liu, Pengfei Li, Sheng Chen, Xuechen Li
Investigation on the substrate specificity and N -substitution tolerance of PseF in catalytic transformation of pseudaminic acids to CMP-Pse derivatives. Chemical science 15 (16) (2024)
Shunhe Liu, Yang Tang, Sheng Chen, Xuechen Li, Han Liu
Total Syntheses of Streptamidine and Klebsazolicin Using Biomimetic On-Resin Ring-Closing Amidine Formation. Angewandte Chemie (International ed. in English) (2024)
Yisa Xiao, Haiyan Zhou, Han Liu, Xuechen Li
Trifluoroacetic Acid Mediated Additive-Free Late-Stage Native Peptide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones. Organic letters 26 (30) (2024)
Peizhong Chen, Xiong Chen, Xiaolei Song, An He, Yong Zheng, Xuechen Li, Rui-Jun Tian
Dissecting phospho-motif-dependent Shc1 interactome using long synthetic protein fragments. Chemical science (2024)
Hongxiang Wu, Zhenquan Sun, Xuechen Li
Selective Peptide Cysteine Manipulation on Demand and Difficult Protein Chemical Synthesis Enabled by Controllable Acidolysis of N,S-Benzylidene Thioacetals. Angewandte Chemie (International ed. in English) 63 (19) (2024)
Hongxiang Wu, Yi Tan, Wai Lok Ngai, Xuechen Li
Total synthesis of interleukin-2 via a tunable backbone modification strategy. Chemical science 14 (6) (2023)
Carina Hey Pui Cheung, Tin Hang Chong, Tongyao Wei, Han Liu, Xuechen Li
Guanidine Additive Enabled Intermolecular ortho-Phthalaldehyde-Amine-Thiol Three-Component Reactions for Modular Constructions. Angewandte Chemie (International ed. in English) 62 (10) (2023)
Carina Hey Pui Cheung, Tin Hang Chong, Tongyao Wei, Han Liu, Xuechen Li
Guanidine Additive Enabled Intermolecular ortho-Phthalaldehyde-Amine-Thiol Three-Component Reactions for Modular Constructions. Angewandte Chemie (International ed. in English) (2023)
Tongyao Wei, Jiamei Liu, Can Li, Yi Tan, Ruohan Wei, Jinzheng Wang, Hongxiang Wu, Qingrong Li, Heng Liu, Yubo Tang, Xuechen Li
Revealing the extracellular function of HMGB1 N-terminal region acetylation assisted by a protein semi-synthesis approach. Chemical science 14 (37) (2023)
Yue Zhang, Ruijuan Yin, Hao Jiang, Chaoming Wang, Xiao Wang, Dongping Wang, Kai Zhang, Ri-Lei Yu, Xuechen Li, Tao Jiang
Peptide Stapling through Site-Directed Conjugation of Triazine Moieties to the Tyrosine Residues of a Peptide. Organic letters (2023)
Hongxiang Wu, Yi Tan, Wai Lok Ngai, Xuechen Li
Total synthesis of interleukin-2 via a tunable backbone modification strategy. Chemical science 14 (6) (2023)
Carina Hey Pui Cheung, Tin Hang Chong, Tongyao Wei, Han Liu, Xuechen Li
Guanidine Additive Enabled Intermolecular ortho-Phthalaldehyde-Amine-Thiol Three-Component Reactions for Modular Constructions. Angewandte Chemie (International ed. in English) 62 (10) (2023)
Wenjie Ma, Hongxiang Wu, Sha Liu, Tongyao Wei, Xiang David Li, Han Liu, Xuechen Li
Chemical Synthesis of Proteins with Base-Labile Posttranslational Modifications Enabled by a Boc-SPPS Based General Strategy Towards Peptide C-Terminal Salicylaldehyde Esters. Angewandte Chemie (International ed. in English) (2022)
Hongfei Jiang, Qing Zhang, Yue Zhang, Huxin Feng, Hao Jiang, Fan Pu, Ri-Lei Yu, Zheng Zhong, Chaoming Wang, Yi Man Eva Fung, Pilar Blasco, Yongxin Li, Tao Jiang, Xuechen Li
Triazine-pyridine chemistry for protein labelling on tyrosine. Chemical communications (Cambridge, England) 58 (50) (2022)
Hoi Yee Chow, Kathy Hiu Laam Po, Sheng Chen, Xuechen Li
Studies on daptomycin lactam-based analogues. Journal of peptide science : an official publication of the European Peptide Society 28 (12) (2022)
Hua-Rui Gong, Ye-Fan Hu, Xuechen Li, Thomas Yau, Bao-Zhong Zhang, Jian-Dong Huang
Non-Neutralizing Epitopes Shade Neutralizing Epitopes against Omicron in a Multiple Epitope-Based Vaccine. ACS infectious diseases (2022)
Tongyao Wei, Dongfang Li, Yue Zhang, Yubo Tang, Haiyan Zhou, Han Liu, Xuechen Li
Thiophene-2,3-Dialdehyde Enables Chemoselective Cyclization on Unprotected Peptides, Proteins, and Phage Displayed Peptides. Small methods 6 (11) (2022)
Hongxiang Wu, Tongyao Wei, Wai Lok Ngai, Haiyan Zhou, Xuechen Li
Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains. Journal of the American Chemical Society 144 (32) (2022)
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang, Xuechen Li
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. RSC chemical biology 2 (4) (2021)
Ruohan Wei, Xuemei Yang, Han Liu, Tongyao Wei, Sheng Chen, Xuechen Li
Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection. ACS central science 7 (9) (2021)
Jinzheng Wang, Du'an Lin, Ming Liu, Han Liu, Pilar Blasco, Zhenquan Sun, Yan Chu Cheung, Sheng Chen, Xuechen Li
Total Synthesis of Mannopeptimycin β via β-Hydroxyenduracididine Ligation. Journal of the American Chemical Society 143 (32) (2021)
Xuechen Li, Todd L Lowary, Pierre-Alexandre Driguez, Nicola L B Pohl, Jianglong Zhu
A New Era of Discovery in Carbohydrate Chemistry. The Journal of organic chemistry 85 (24) (2021)
Hongxiang Wu, Yiwei Zhang, Yuanxin Li, Jianchao Xu, Yu Wang, Xuechen Li
Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms. Journal of the American Chemical Society 143 (20) (2021)
Jiamei Liu, Tongyao Wei, Yi Tan, Heng Liu, Xuechen Li
Enabling chemical protein (semi)synthesis via reducible solubilizing tags (RSTs). Chemical science 13 (5) (2021)
Hongxiang Wu, Yiwei Zhang, Yuanxin Li, Jianchao Xu, Yu Wang, Xuechen Li
Correction to "Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms". Journal of the American Chemical Society 143 (25) (2021)
Xing Guo, Xuling Chen, Yuyu Cheng, Xiaoyong Chang, Xuechen Li, Pengfei Li
Organocatalytic enantioselective [2 + 4]-annulation of γ-substituted allenoates with N-acyldiazenes for the synthesis of optically active 1,3,4-oxadiazines. Organic & biomolecular chemistry 19 (8) (2021)
Carina Hey Pui Cheung, Jianchao Xu, Chi Lung Lee, Yanfeng Zhang, Ruohan Wei, Donald Bierer, Xuhui Huang, Xuechen Li
Construction of diverse peptide structural architectures via chemoselective peptide ligation. Chemical science 12 (20) (2021)
Lili Du, Zhiping Yan, Zhiyuan Zhu, Shun-Cheung Cheng, Yue Zhang, Xuechen Li, Wen Jian Tang, David Lee Phillips
Time-Resolved Spectroscopic Observation of Diphenylnitrenium Ion Reactions with Guanosine. The Journal of organic chemistry 85 (14) (2020)
Yi Tan, Hongxiang Wu, Tongyao Wei, Xuechen Li
Chemical Protein Synthesis: Advances, Challenges, and Outlooks. Journal of the American Chemical Society (2020)
Jizhuang Wang, Ze Xiong, Ming Liu, Xiao-Meng Li, Jing Zheng, Xiaojun Zhan, Weiting Ding, Jianan Chen, Xuechen Li, Xiang David Li, Shien-Ping Feng, Jinyao Tang
Rational Design of Reversible Redox Shuttle for Highly Efficient Light-Driven Microswimmer. ACS nano 14 (3) (2020)
Hoi Yee Chow, Delin Chen, Xuechen Li
Improved total synthesis of the antibiotic A54145B. Organic & biomolecular chemistry (2020)
Delin Chen, Kathy Hiu Laam Po, Pilar Blasco, Sheng Chen, Xuechen Li
Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation. Organic letters 22 (12) (2020)
Hoi Yee Chow, Kathy Hiu Laam Po, Peng Gao, Pilar Blasco, Xiukun Wang, Congran Li, Lianwei Ye, Kang Jin, Kaichao Chen, Edward Wai Chi Chan, Xuefu You, Richard Yi Tsun Kao, Sheng Chen, Xuechen Li
Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens. Journal of medicinal chemistry 63 (6) (2020)
Zhenquan Sun, Zhuo Shang, Nicholas Forelli, Kathy Hiu Laam Po, Sheng Chen, Sean F Brady, Xuechen Li
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment. Angewandte Chemie (International ed. in English) 59 (45) (2020)
Yi Tan, Jiasheng Li, Kang Jin, Jiamei Liu, Ziyong Chen, Jun Yang, Xuechen Li
Cysteine/Penicillamine Ligation Independent of Terminal Steric Demands for Chemical Protein Synthesis. Angewandte Chemie (International ed. in English) 59 (31) (2020)
Heng Liu, Han Liu, Xuechen Li
Use of Serine/Threonine Ligation for the Total Chemical Synthesis of HMGA1a Protein with Site-Specific Lysine Acetylations. ChemPlusChem 84 (7) (2019)
Yue Zhang, Qing Zhang, Clarence T T Wong, Xuechen Li
Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides. Journal of the American Chemical Society 141 (31) (2019)
Qing Zhang, Yue Zhang, Heng Liu, Hoi Yee Chow, Rui-Jun Tian, Yi Man Eva Fung, Xuechen Li
OPA-Based Bifunctional Linker for Protein Labeling and Profiling. Biochemistry 59 (2) (2019)
Delin Chen, Hoi Yee Chow, Kathy Hiu Laam Po, Wenjie Ma, Emily Lok Yee Leung, Zhenquan Sun, Ming Liu, Sheng Chen, Xuechen Li
Total Synthesis and Structural Establishment/Revision of Antibiotics A54145. Organic letters 21 (14) (2019)
Ruohan Wei, Han Liu, Arthur H Tang, Richard J Payne, Xuechen Li
A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation. Organic letters 21 (10) (2019)
Yu Zhang, Yujie Liang, Feng Huang, Yue Zhang, Xuechen Li, Jiang Xia
Site-Selective Lysine Reactions Guided by Protein-Peptide Interaction. Biochemistry 58 (7) (2019)
Hoi Yee Chow, Yue Zhang, Eilidh Matheson, Xuechen Li
Ligation Technologies for the Synthesis of Cyclic Peptides. Chemical reviews 119 (17) (2019)
Changcheng Wang, Yue Yu, Zhengquan Su, Xuechen Li, Hua Cao
Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes. Organic letters 21 (12) (2019)
Han Liu, Xuechen Li
Serine/Threonine Ligation: Origin, Mechanistic Aspects, and Applications. Accounts of chemical research 51 (7) (2018)
Daji Yang, Yue Yu, Yuanheng Wu, Huiyi Feng, Xuechen Li, Hua Cao
One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2-(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols. Organic letters 20 (8) (2018)
Gloria Andolina, Ruohan Wei, Han Liu, Qing Zhang, Xuemei Yang, Huiluo Cao, Sheng Chen, Aixin Yan, Xiang David Li, Xuechen Li
Metabolic Labeling of Pseudaminic Acid-Containing Glycans on Bacterial Surfaces. ACS chemical biology 13 (10) (2018)
Kang Jin, Xuechen Li
Advances in Native Chemical Ligation-Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (66) (2018)
Kang Jin, Tianlu Li, Hoi Yee Chow, Han Liu, Xuechen Li
P-B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site-Specific Deuteration. Angewandte Chemie (International ed. in English) 56 (46) (2017)
Han Liu, Yanfeng Zhang, Ruohan Wei, Gloria Andolina, Xuechen Li
Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de Novo Synthesis of Pseudaminic Acid. Journal of the American Chemical Society 139 (38) (2017)
Changcheng Wang, Jialin Lai, Cantao Chen, Xuechen Li, Hua Cao
Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles. The Journal of organic chemistry 82 (24) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Xuechen Li