Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome.

Thomas G NührenbergMarco CederqvistFederico MariniChristian StratzBjörn A GrüningDietmar TrenkHarald BinderRalf GilsbachFranz-Josef NeumannLutz Hein

Published in: BioMed research international (2018)

In this study, uncontrolled DM had a remote impact on different components of the platelet transcriptome. Increased expression of MACF1, together with supporting predicted mRNA-miRNA interactions as well as reduced expression of RNYs in platelets, may reflect subclinical platelet activation in uncontrolled DM.

Keyphrases

poor prognosis
rna seq
binding protein
gene expression
single cell
genome wide
glycemic control
type diabetes
skeletal muscle
insulin resistance
weight loss