Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.

Bradley N MillsHaoming QiuMichael G DrageChunmo ChenJocelyn S MathewJesse Garrett-LarsenJian YeTaylor P UccelloJoseph D MurphyBrian A BeltEdith M LordAlan W KatzDavid C LinehanScott A Gerber

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These findings suggest that SBRT augmentation of antitumor immunogenicity may be dampened by an overabundance of refractory immunosuppressive populations, and support the continued development of SBRT/immunotherapy combination for human PDAC.

Keyphrases

endothelial cells
radiation therapy
induced pluripotent stem cells
stem cells
early stage
pluripotent stem cells
squamous cell carcinoma