Mental Health, ART Adherence, and Viral Suppression Among Adolescents and Adults Living with HIV in South Africa: A Cohort Study.
Andreas D HaasRaphael LienhardChristiane DiddenMorna CornellNaomi FolbTebatso M G BoshomaneLuisa Salazar-VizcayaYann RuffieuxPatience NyakatoAnja E WettsteinMpho TlaliMary-Ann DaviesPer von GrooteMilton WainbergMatthias EggerGary MaartensJohn A JoskaPublished in: AIDS and behavior (2023)
We followed adolescents and adults living with HIV aged older than 15 years who enrolled in a South African private-sector HIV programme to examine adherence and viral non-suppression (viral load > 400 copies/mL) of participants with (20,743, 38%) and without (33,635, 62%) mental health diagnoses. Mental health diagnoses were associated with unfavourable adherence patterns. The risk of viral non-suppression was higher among patients with organic mental disorders [adjusted risk ratio (aRR) 1.55, 95% confidence interval (CI) 1.22-1.96], substance use disorders (aRR 1.53, 95% CI 1.19-1.97), serious mental disorders (aRR 1.30, 95% CI 1.09-1.54), and depression (aRR 1.19, 95% CI 1.10-1.28) when compared with patients without mental health diagnoses. The risk of viral non-suppression was also higher among males, adolescents (15-19 years), and young adults (20-24 years). Our study highlights the need for psychosocial interventions to improve HIV treatment outcomes-particularly of adolescents and young adults-and supports strengthening mental health services in HIV treatment programmes.
Keyphrases
- mental health
- young adults
- hiv positive
- antiretroviral therapy
- hiv infected
- south africa
- sars cov
- hiv testing
- human immunodeficiency virus
- physical activity
- men who have sex with men
- hepatitis c virus
- mental illness
- hiv aids
- end stage renal disease
- newly diagnosed
- healthcare
- depressive symptoms
- ejection fraction
- health insurance
- chronic kidney disease
- skeletal muscle
- randomized controlled trial
- prognostic factors
- adipose tissue
- study protocol
- peritoneal dialysis
- weight loss
- sleep quality
- metabolic syndrome
- smoking cessation
- replacement therapy
- insulin resistance