Association of Drug-Metabolizing Enzyme and Transporter Gene Polymorphisms and Lipid-Lowering Response to Statins in Thai Patients with Dyslipidemia.

Natchaya VanwongSayanit TipnoppanonChalitpon Na NakornPornpen SrisawasdiPunyanuch RodcharoenSadeep MedhasiPajaree ChariyavilaskulSarawut SiwamogsathamYongkasem VorasettakarnkijChonlaphat Sukasem

Published in: Pharmacogenomics and personalized medicine (2022)

This pharmacogenomic study identifies new genetic variants of DMET genes that are associated with the lipid-lowering response to statins. Genetic polymorphisms in DMET genes may impact the pharmacokinetics and lipid-lowering response to statin. The validation studies confirmations are needed in future pharmacogenomic studies.

Keyphrases

genome wide
cardiovascular disease
fatty acid
case control
clinical decision support
coronary artery disease
dna methylation
emergency department
current status